The Eugene Cook collection primarily consists of numerous photographs in various forms (prints, negatives, slides, contact prints, etc.), most of which were taken for the Time-Life company. In addition to the hundreds of photographs, the papers include some printed material, correspondence, subject files, audio recordings, notebooks, and other material.
Many of the photographs were categorized by Cook into various sections, including: celebrity, world, opera, theater, music, Phyllis Curtin (his wife), The Ford Foundation, House Beautiful, and other subjects. Notable individuals with images in the collection include Marcel Marceau, Lee Remick, Patty Duke, Deborah Kerr, Orson Welles, Kim Novak, Jacqueline Brooks, Jean Seberg, Leslie Caron, Sandra Dee, Marianne Kanter, Gina Lollobrigida, Fabian, Colleen Dewhurst, Julie Harris, Ingrid Bergman, Susan Haywood, Harry Belafonte, Carol Burnett, Shirley Booth, Edward Binns, Julie Andrews, Danny Kaye, Frankie Avalon, Paul Anka, Perry Como, Steve Allen, Dick Clark, Red Buttons, Ilse Peterson, Paola Neori, Susan Strasberg, Paddy Chayefsky, William Inge, Tyrone Power, Jane Powell, Ezio Pinza, Frederic March, Cornelius Ryan, Leontyne Price, Anthony Perkins, Patti Page, Frank Sinatra, Tony Randall, Risë Stevens, Walter Winchell, Bob Evans, Judy Garland, Kirk Douglas, Anita Ekberg, Noël Coward, Vera Miles, Milton Berle, Sophia Loren, and many others.